Activation of AURKB induces the development of pancreatic cancer.[66] AURKB has been identified as a DEG of SARS-CoV-2 in Caco-2 cells.[67] TPX2 is a protein-coding gene crucial for spindle assembly and accurate chromosome segregation during mitosis, thereby playing an essential role in cell division and maintaining genomic stability.[68] The expression of TPX2 is significantly higher in pancreatic tumors compared to normal tissues. The gene discussed is TPX2; the disease is familial pancreatic carcinoma.