Additionally, protein–protein interaction (PPI) analysis identified the top 10 hub genes: ESPL1, HJURP, MKI67, KIF4A, CDK1, TOP2A, CCNB2, UBE2C, AURKB, and TPX2, which may serve as therapeutic targets for both COVID-19 and PC. Here, ESPL1 is linked to pachyonychia congenita.