EGFR and familial pancreatic carcinoma: Additionally, UBE2C has been shown to bind to the epidermal growth factor receptor, stabilizing it and further activating the PI3K-Akt pathway, thereby promoting the progression of pancreatic cancer.[64] A transcriptome sequencing study of peripheral blood of patients with pneumonia found that UBE2C expression was higher in patients with severe pneumonia than in patients with mild pneumonia.[65] AURKB is a protein-coding gene that plays a crucial role in chromosome alignment, segregation, and cytokinesis during mitosis.