ACE2 and COVID-19: This widespread presence of ACE2 explains why COVID-19 can affect multiple organ systems, making it a systemic disease.[5] The systemic nature of COVID-19 can lead to a variety of complications beyond respiratory issues, such as cardiovascular, renal, gastrointestinal, and hepatic problems.[6] Thus, it is imperative to investigate the mechanisms by which COVID-19 interacts with other diseases, as this knowledge could reveal potential therapeutic targets and inform strategies to mitigate the multifaceted impacts of the virus.