NLRP3 and diabetic kidney disease: In a study of diabetic nephropathy, which contained in vitro and in vivo data, NLRP3 inflammasome was found to be activated.[42] NLRP3 inflammasome activity may be involve in the blood pressure fluctuation and kidney injury.[43] Overall, NLRP3 may be a potential systemic inflammatory biomarker, which could reflect not only renal injury, but also systemic injury.