Metformin hydrochloride is widely used as an insulin sensitizer for the treatment of PCOS due to its ability to alleviate hyperinsulinemia and hyperandrogenism associated with the condition, thereby facilitating ovulation.[7] Metformin also acts synergistically to reduce levels of luteinizing hormone (LH) and androgens in the bloodstream.[8] However, the oral administration of metformin alone in PCOS treatment typically provides only temporary relief from clinical symptoms. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.