Moreover, intracellular processes are highly influences by ROS concentrations.[56] Oxidative stress is induced by high angiotensin (Ang) II and low Ang 1-7 levels, and negatively affects cell and tissue function.[57] In addition, overactivation of the immune response, characterized by the production of proinflammatory cytokines, is common in patients with COVID-19 and is another trigger of endogenous oxidative stress.[58] As mentioned earlier, inflammation and oxidative stress play important roles in COVID-19 and AS comorbidity. The gene discussed is ANGPT1; the disease is COVID-19.