MTOR and renal cell carcinoma: EdU and Colony-formation experiments presented that suppression of ABHD5 significantly regained RCC cell growth inhibition mediated by FOXC1 overexpression (Fig. 7A and B).In RCC cells, the inhibition of ABHD5 reversed the migration and invasion suppression caused by overexpression of FOXC1, as demonstrated by scratch test and transwell experiment (Fig. 7C and D).Finally, western blot assay showed that overexpression of FOXC1 activated AMPK signal pathway to suppress mTOR signal pathway, whereas suppression of ABHD5 reversed these effects (Fig. 7E).