Moreover, CAF2 was predicted to interact with tumor endothelial cells (TECs) including tip cell and venous TECs via the ANGPT2-(ITGA5 + ITGB1) and PGF-VEGFR1 axes, suggesting a role in promoting endothelial cell proliferation and migration (Fig. 3H). The gene discussed is ITGB1; the disease is neoplasm.