CD8A and non-small cell lung carcinoma: We found the D(CD4+Tregs) in TC (65.03 vs. not reached, P = 0.011) and D(CD8+Tregs) in IM and TC (IM, 68.00 vs. not reached, P = 0.018; TC, 62.03 vs. not reached, P = 0.001) were associated with the better prognosis of NSCLC patients via the log-rank test and the Kaplan–Meier method (Supplementary file 1: Fig. S2).