Among the 10 genes affected by obesity, 7 were expressed at lower levels potentially indicating a decrease in DNA repair capacity: HDAC1 (−20.0%, P = 0.01), PARP1 (−23.6%, P = 0.02), BLM (−35.2%, P < 0.023), FEN1 (−34.0%, P = 0.013), XPA (−4.8%, P < 0.001), and POLG (−7.8%, P = 0.04). Here, HDAC1 is linked to obesity due to melanocortin 4 receptor deficiency.