Based on a retrospective analysis of a nationwide Japanese cohort survey from 1998 to 2009, Shimamura et al. 2 proposed extended criteria, the 5-5-500 rule (largest nodule size less than or equal to 5 cm in diameter, number of nodules less than or equal to 5, and α-fetoprotein (AFP) value less than or equal to 500 ng/ml), for living donor LT (LDLT) in patients with HCC. Here, AFP is linked to hepatocellular carcinoma.