HTR2A and psychotic disorder: Thisis an important and relevant challenge as clinically, this off-targetprofile leads to undesirable extrapyramidal side-effects in the treatmentof psychosis.52 To achieve this, this objectiveaims to minimize the docking score against 5-HT2A (PDB: 6A93), yet maximize the docking score against D2 (PDB: 6CM4), within a budgetof 32,000 molecules.