Al‐Kuraishy et al. observed that metformin increases the expression and release of GDF15, which has a protective effect against thrombosis and inflammation in T2DM patients, and they also reported that increasing the circulating GDF15 level in AS and T2DM patients could be a compensatory mechanism to mitigate and overcome oxidative stress and inflammatory disorders.69 Here, GDF15 is linked to type 2 diabetes mellitus.