Moreover, oxidative stress suppresses the endogenous antioxidant defense system, including Nuclear factor erythroid 2-related factor 2 (NRF2), Novel Heme Oxygenase-1 (HO-1), and triggers oxidative markers such as Nuclear Factor Kappa B (Nfkβ) and Toll-Like Receptor TLR4, leading to neuroinflammation, synaptotoxicity and memory impairment [13, 14]. This evidence concerns the gene NFE2L2 and memory impairment.