PIK3CA and pachyonychia congenita: To compare the growth‐inhibitory effects of multi‐node versus single‐node PAM inhibitors, seven PC cell lines were tested for cell viability in response to treatment with gedatolisib, samotolisib (pan‐PI3K/mTOR inhibitors), capivasertib (AKT inhibitor), alpelisib (PI3Kα inhibitor), or everolimus (mTORC1 inhibitor) (Fig. 1B).