Women with PCOS and obesity underwent lifestyle modification, including calorie-restricted diet and physical exercise. After completion of the intervention, they were divided on their ovulation status into resumed ovulation (OR-) and anovulatory group. Only AMH concentration was significantly lower in the OR- group. Anthropometric measures, baseline characteristics, insulin, FAI, T, and HOMA-IR did not vary significantly. The gene discussed is AMH; the disease is obesity due to melanocortin 4 receptor deficiency.