LEP and metabolic syndrome: Severely obese women with or without metabolic syndrome who underwent Roux-en-Y gastric bypass (RYGB) surgery displayed significant positive changes in body mass index (BMI), body weight, glucose levels, low-density lipoprotein (LDL) cholesterol, total cholesterol, high-density lipoprotein (HDL) cholesterol, leptin, adiponectin, and the ratio between adiponectin and leptin.