INS and peripheral arterial disease: T2DM is drawing a connection between several metabolic aberrations [30,31] that comprise IR and fall-off insulin synthesis [18,32,33], leading to sustained high blood glucose levels and the breach of the normal lipid metabolism process (e.g., cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides, and HDL-C) [34], which germinates hypertension, coronary artery disease (CAD), myocardial infarction (MI), stroke, peripheral arterial disease (PAD), and sequentially glares CVD [33,35].