Patients with metabolic syndrome and glucose intolerance or T2DM were prescribed a unique food supplement comprising D-chiro-inositol, glucomannan, Cinnamomum zeylanicum Blume, and inulin. At 16 weeks of follow-up, it was observed that body weight, BMI, insulin, and Homa index were reduced, and there was a more remarkable improvement in TG, cholesterol, and LDL levels. This evidence concerns the gene INS and Glucose intolerance.