CAT and Sepsis: Administration of meldonium at a dose of 300 mg/kg bw/day for four weeks before inducing sepsis in animals showed an increased activity of tissue copper-zinc SOD, manganese SOD, catalase (CAT), and glutathione peroxidase (GSH-Px) and reduced levels of lipid peroxidation, TNFα, phospho-nuclear factor kappa B p65 form (p-NF-κB p65), and the Bax/Bcl-2 apoptotic marker ratio, suggesting the anti-inflammatory and anti-apoptotic effects of meldonium [31,32].