Subsequently, the elevated β‐catenin is transferred into nucleus and then binds to TFs such as T cell factor/lymphoid enhancer factor (TCF/LEF), eventually leading to activation of target genes including Snail, ZEB, Twist, MMPs, and c‐Myc, a main carcinogenic driver of tumor progression (Figure 3).93, 94, 95, 96. The gene discussed is TWIST1; the disease is neoplasm.