In addition, TGF‐β promotes the expression of differentiated embryo‐chondrocyte expressed gene 1 (DEC1), a helix‐loop‐helix (bHLH) TF, and the dysregulated DEC1 is found to participate in the TGF‐β‐mediated EMT, resulting in tumor metastasis.88, 89. This evidence concerns the gene TF and neoplasm.