PERK upregulates the expression of autophagy‐related gene genes to induce autophagy through eukaryotic translation initiation factor 2α (eIF2α)‐activating TF 4‐C/EBP homologous protein (CHOP) pathway, and the activated autophagy facilitates tumor cells to better survive under oxidative stress as well as resist anoikis.208. The gene discussed is DDIT3; the disease is neoplasm.