It is possible that GC and PTH(1-34)-dependent effects on the joint (98–102) would be more apparent with injury, since suppressed PLR exacerbated post-traumatic osteoarthritis in male mice with an osteocyte-intrinsic deletion of transforming growth factor, beta receptor II (Tgfβr2) (20). Here, TGFBR2 is linked to osteoarthritis.