In this study, we showed that SHD inhibited cell proliferation, migration, and invasion abilities, as well as promoted apoptosis of HS683 and KNS89 cells in vitro. Furthermore, when we combined SHD with TMZ to treat HS683 tumor-bearing mice, we found that the inhibition of tumor growth on SHD + TMZ was significantly strengthened compared to alone TMZ group, as accompanied by a reduction of Bcl-2, vimentin, PIK3CA, AKT1, CTNNB1, STAT3, EGFR, VEGFA, ERBB2, and HIF1A expressions and an increase of Bax, Caspase-3, E-cadherin, and TP53 levels in vitro and in vivo. This evidence concerns the gene TP53 and neoplasm.