NOTCH1 and malignant colon neoplasm: Cucurbitacin B and I, decrease the expression of Notch receptors and ligands, repressing the activity of gamma-secretases, suppressing NICD production, binding to Notch1, subsequently repressing downstream genes of Notch, inhibiting tumor growth in colon cancer (Dandawate et al., 2020; Mccaw et al., 2021).