Crosstalk between PI3K/AKT and Notch pathways has been described in prostate cancer (Wang et al., 2011a), T-ALL (Cecchinato et al., 2007), colon cancer (Koduru et al., 2009), brain cancer (Xiang et al., 2020) as well as breast cancer (Cao et al., 2018). Here, AKT1 is linked to acute lymphoblastic leukemia.