SRY and autism: Mouse models that allow for the separation of gonadal sex and sex chromosomes by the deletion of the Sry gene from chrY and insertion of a Sry transgene into an autosome (known as the four core genotypes model) (2) have found that the presence of only 1 chrY or the absence of 2 chrXs irrespective of gonadal sex increased male bias in a maternal antibody–induced model of autism (85).