Vitamin-D can reduce the level of NF-kB, strengthen the phagocytic ability of phagocytes, reduce the production of inflammatory factors and proteases, and alleviate the degree of lung tissue damage.17,18 Yang H et al.19 confirmed that intervention with Vitamin-D in patients with COPD on the basis of routine treatment can effectively improve lung function, upregulate immune function related indicators, and help alleviate the severity of the patient’s condition. This evidence concerns the gene NFKB1 and chronic obstructive pulmonary disease.