The results of our study showed that the serum levels of TNF-α, IL-1 and IL-6 in the combination group were lower than those in the Irbesartan group after the treatment, which further confirmed that the combination of atorvastatin and irbesartan can effectively reduce the micro-inflammatory state and may, therefore, have a higher application value in early DN. The gene discussed is TNF; the disease is liver dysplastic nodule.