IL-8 promotes tissue angiogenesis and increases the chances of tumor metastasis.27,28 At the same time, IL-10 can suppress the proliferation and differentiation of T cells and down-regulate the body’s anti-tumor response.27-29because of their low selectivity, most small molecule inhibitors of VEGFR2 tyrosine kinase show unexpected adverse effects and limited anticancer efficacy. This evidence concerns the gene KDR and neoplasm.