CD8A and Epstein-Barr virus infection: Interferon had a very obvious anti-EBV infection effect in vivo, but not obvious in vitro, and the reaction could instantaneously inhibit virus replication and weaken the amplification of CD8+ T-lymphocytes without the need to control primary infection.18 Barrat et al.19 suggested that interferon had the ability of inducing “interferon epigenomic characteristics” by activating potential enhancers and “labeling” chromatin, with certain beneficial effects on anti-virus response, antigen presentation, autoimmune and inflammatory molecules.