One study showed that L-Selectin levels decreased with a higher number of risk factors (smoking, hypertension, diabetes mellitus, or hypercholesterolemia) one risk factor: 777.35 ng/mL (SEM:114.03) vs. four risk factors: 692.75 ng/mL (SEM: 112.60) (65). This evidence concerns the gene SELL and familial hypercholesterolemia.