Another study investigated 915 AIS patients and 90 stroke mimics and reported that the best sensitivity and specificity calculated by ROC analysis were found for caspase-3, D-dimer, soluble Receptor for Advanced Glycation End Products (sRAGE), Chimerin-II, secretagogin, and MMP-9, which formed the basis of the biomarker panel. This evidence concerns the gene CASP3 and stroke disorder.