CDK7 and neoplasm: used a combination of in-vitro human OS cell lines along with three-dimensional (3D) culture models and tumor-bearing mice to identify the cyclin-dependent kinase 7 (CDK7) as a key player in OS growth and metastasis, resulting in the conclusion that targeting CDK7 or its target glucose-related protein 78-kDa (GRP78) presents a potential treatment strategy for OS (118).