WHO classification of tumors of soft tissue and bone in 2020 added a new category of “undifferentiated small round cell sarcomas of bone and soft tissue tumors” that now includes Ewing sarcoma and three new entities: EWSR1::non-ETS fusions, CIC-rearranged sarcoma, and sarcomas with BCOR genetic alterations along with prototypical Ewing sarcoma arising in bone or soft tissue (89). The gene discussed is EWSR1; the disease is sarcoma.