Adistinct mixture Artesunate-phosphatidylcholine (ARTPC) encapsulated with temozolomide (ApoE-ARTPC@TMZ) is the basis of an ApoE-functionalized liposomal nanoplatform that has been shown to effectively co-deliver dual therapeutic drugs to TMZ-resistant U251-TR GBM in vivo. Here, APOE is linked to glioblastoma.