Oligodendrocytes downregulated secretion of inflammatory response associated proteins such as gelsolin (Gsn), an actin depolymerizing protein describe has having a modulatory role in inflammation [30] , Masp-1, an activator of the complement pathway, Brevican (Bcan), a CSPG which has been shown to be secreted after brain injury by reactive astrocytes [31], and pleiotrophin (Ptn), a trophic factor upregulated in diseases characterized by neuroinflammation such as Alzheimer’s disease and Parkinson’s disease [32, 33] (Figure 3C). Here, GSN is linked to early-onset autosomal dominant Alzheimer disease.