UNC13A and amyotrophic lateral sclerosis: rs12608932 within UNC13A is a validated genetic modifier of ALS survival.18 For 5,498 patients from Project MinE (www.projectmine.com) we first predicted survival using our optimum ensemble model, and then used Cox regression with platform and first 10 PCs as covariates to test the effect of the rs12608932(C) allele on predicted survival.