However, two melanoma cases with nevoid morphology were PRAME−, consistent with the previously reported loss PRAME immunoreactivity in nevoid and desmoplastic melanoma (47, 51); 5hmC levels were high in our nevoid melanomas, further demonstrating the inverse correlation between PRAME and 5hmC (combined results of the two cohorts are summarized in Figure 1C, supplementary Figure 1C and supplementary Table 1). The gene discussed is PRAME; the disease is melanoma.