Using the ephrinB2fl/flTie2Cre (ephrinB2 KO) mouse model (Figure 4A) (Bhatia et al., 2022) implanted with MOC2 cancer cells, we found that deletion of vascular ephrinB2 coupled with RT significantly reduced local tumor growth compared to wild-type (WT) hosts (Figure 4B, Suppl. This evidence concerns the gene EFNB2 and neoplasm.