Comparison of transcriptomic changes between MOC2 control and EphB4 knockout cell lines showed higher expression of TGF beta receptors 1 and 2, NOTCH1, and FOXC1, a transcription factor implicated in cancer cell plasticity, treatment resistance, invasion, and epithelial-mesenchymal transition (EMT) (Figure 2A) (Ray et al., 2021; Zhu et al., 2017). This evidence concerns the gene NOTCH1 and cancer.