EPHB4 and head and neck squamous cell carcinoma: However, many studies on EphB4-ephrinB2 signaling in HNSCC metastasis have been limited to descriptive correlations and/or heavy reliance on in vitro experiments (Masood et al., 2006; Sasabe et al., 2017; Sinha et al., 2006; Yi et al., 2021).