CEACAM1 and bacterial infectious disease: stressed that type I IFN could reduce the inflammation responses by enhancing the expression of The Carcinoembryonic Antigen-related Cell Adhesion Molecules (CEACAM) 1 due to negative interactions between Moraxella and CEACAM1. These research findings align with the hypothesis that type I IFNs are protective in acute viral infections but can have either protective or deleterious roles in bacterial infections (Trinchieri, 2010).