In logistic regression models adjusted for age, sex, hypertension, atrial fibrillation, history of previous smoking, diabetes and hyperlipidemia, increased levels of IL-9 (OR 1.359, 95%CI 1.046–1.766, p = 0.022), IL-17 (OR 1.491, 95%CI 1.115–1.994, p = 0.007) and TNF-α (OR 1.440, 95%CI 1.089–1.904, p = 0.011) were independently associated with angiographically detected CAD. This evidence concerns the gene TNF and diabetes mellitus.