In summary, our investigation revealed that BDS-hEA induces autophagy in vascular endothelial cells and HCC tumors by activating AMPK and suppressing AKT/mTOR signaling pathways and that autophagy inhibition blocks the BDS-hEA-induced functions of vascular endothelial cell proliferation, metastasis, and angiogenesis as well as HCC tumor growth. Here, MTOR is linked to hepatocellular carcinoma.