Expression of the endostatin (collagen α1-chain XVIII C-terminal hydrolytic fragment) and angiostatin (amino-terminal proteolytic fragment of plasmin) fusion protein using this vector (BacSC-DAF-SB-T2ChEA, abbreviated as BDS-hEA) exhibited enhanced and sustained inhibition of vascular endothelial cell angiogenesis, proliferation, and migration, along with significant suppression of HCC tumor growth in mice [5]. The gene discussed is COL18A1; the disease is hepatocellular carcinoma.