DNM2 and fibrosis: The adhesion between transdifferentiated epithelial cells exhibited a decrease, accompanied by alterations in the composition of cytoskeletal proteins and an increase in migration ability, thus resulting in excessive deposition of extracellular matrix, periepithelial fibrosis, exacerbation of parenchymal structure damage in the small airways affected by COPD, and consequent airflow restriction [26,27].