For example, in the gastric cancer cell line, SNU16, at least three distinct species of ecDNA exist independently from chromosomes; those that localize the MYC (chr 8) oncogene, those that localize the FGFR2 (chr 10) oncogene, and those that co-localize MYC (chr 8), FGFR2 and CD44 (chr 11) genes. The gene discussed is FGFR2; the disease is gastric cancer.