The HBV X (HBx) protein activates signaling pathways such as Phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) and Toll-like receptors (TLRs), which influence hepatic lipogenesis, the conversion of cholesterol to bile acids (BAs), and hepatic lipid homeostasis, thereby contributing to hepatic steatosis (6–9). The gene discussed is AKT1; the disease is Hepatic steatosis.