CD4 and neoplasm: By comparing TIICs through the CIBERSORT and ssGSEA algorithms respectively, we found that immune cells with direct tumor killing functions, such as plasma cells and CD8+ T cells, were significantly reduced in the high-risk group, while immune cells with auxiliary functions, such as M0 macrophages, M1 macrophages, and activated CD4+ T cells, were significantly increased in the high-risk group.