The CD4+ T helper 17 (TH17) axis plays a significant role in regulating the immune system in SSH by influencing the activity of TH17 cells and the expression of Interleukin 17A (IL-17) through key factors like SGK1 and NFAT5, potentially contributing to the development of diseases like hypertension (36). The gene discussed is IL17A; the disease is hypertensive disorder.