We searched MEDLINE (PubMed) and Scopus for articles describing the characteristic symptoms of the eight most prevalent diseases associated with T2 inflammation [asthma, chronic rhinosinusitis, allergic rhinitis, allergic conjunctivitis, IgE-mediated food allergy, atopic dermatitis, eosinophilic oesophagitis, and NSAID-exacerbated respiratory disease (NERD)]. The gene discussed is IGHE; the disease is food allergy.