Consistently, in zebrafish carrying a human TARDBP gene (encoding the TDP-43 protein) with a mutation found in fALS forms, optogenetic activation of reticulospinal neurons and of spinal V2a INs was sufficient to elicit ALS-like symptoms characteristic of this animal model, indicating a functional alteration of glutamatergic synapses in the spinal cord (Petel Legare et al., 2019). Here, TARDBP is linked to amyotrophic lateral sclerosis.