Although their number is transiently increased at these early stages (Herron and Miles, 2012; Milan et al., 2015; Bak et al., 2023), a later reduction in C-boutons and degeneration of the V0c INs is observed in symptomatic SOD1 or TDP43 mouse models of ALS (Chang and Martin, 2009; Casas et al., 2013; Milan et al., 2015; Wells et al., 2021; Bak et al., 2023). Here, SOD1 is linked to amyotrophic lateral sclerosis.