Recent research showed that Runx2 promotes aortic and aortic valve fibrosis in models of type 2 diabetes and aging.S3,S4 Transforming growth factor be (TGF‐β1), which is a major factor driving fibrosis, is secreted by cancer cells and promotes the expression and function of Runx2.16 The gene discussed is TGFB1; the disease is cancer.