Moreover, we demonstrated that p73 and, specifically the TAp73 isoform, sustains GSC self‐renewal, being a central regulator of transcriptional networks related to the stemness signature of CSCs, supporting previous reports that postulated that TAp73 positively regulates growth and self‐renewal of CD133+ patient‐derived brain tumor‐initiating cells [14]. Here, TP73 is linked to brain neoplasm.