IGF1 and chronic kidney disease: αKlotho has not only strong antiaging properties, but has also been demonstrated to be highly beneficial in several acute and chronic disorders: It is nephroprotective (e.g., by preventing renal fibrosis in chronic kidney disease (CKD)) [17], cardioprotective (e.g., by inhibiting cardiac remodeling or cardiac fibrosis) [18], or has multiple anticancer effects as a tumor suppressor (e.g., by inhibiting Wnt or insulin‐like growth factor 1 (IGF1)‐dependent phosphoinositide 3‐kinase (PI3K) signaling) [19, 20, 21].