GNAS and pseudohypoparathyroidism type 1A: In some patients, the MLID diagnosis indicates a prognostic risk that additional clinical features might emerge in the future (for example, features of pseudohypoparathyroidism in a person with GNAS imprinting defect [79], or early puberty in a child with 14q32 imprinting defect [80]); surveillance for such potential complications should be included in their management plan.