Hierachical analysis showed that melanoma samples clustered in two groups; one with low GLI1 and GLI2 expression and high cytokine expression (CCL7, CCL2, CCL20, CXCL8, CXCL1 and CXCL10) (GLI Low/Cytokine High), the other group with high GLI1 and GLI2 and low cytokine expression (GLI High/Cytokine Low) (Fig. 8A and B). The gene discussed is CCL20; the disease is melanoma.