RUNX1 and other hematopoietic TFs, TAL1/SCL, GATA2, PU.1, LMO2 and LDB1 bind at RUNX1-SE, which is observed in normal HSCs and T-cell acute lymphoblastic leukemia cells, regulate HSCs differentiation and development [101]. Here, RUNX1 is linked to T-cell acute lymphoblastic leukemia.