Notably, compared with WT BMDMs, the CPT1A activator Lca could neither dampen inflammatory response (Figure S9a–c) nor improve mitochondrial dynamics (Figure S9d) in IL‐10−/− BMDMs, implying that IL‐10 acts as a crucial intermediate regulator for the protective effect of macrophage CPT1A on ALI/ARDS. The gene discussed is CPT1A; the disease is acute respiratory distress syndrome.