CPT1A and acute respiratory distress syndrome: By constructing mice harbouring a conditional depletion of macrophage CPT1A (Cre+CPT1Afl/fl), we identified a significant protective role of CPT1A in reducing lung inflammatory damage in ALI mice, as well as its anti‐inflammatory and mitochondria‐regulatory effects on bone marrow‐derived macrophages (BMDMs) challenged with LPS.