The schematic diagram of the experimental procedure is shown in Fig. 5A. The macroscopic images showed that, compared with WT mice, deletion of TOPK in keratinocytes markedly alleviated psoriasis-like manifestations, including scaling, erythema, and epidermal thickening, whereas after neutrophils depletion, psoriasis-like manifestations became similar between control mice and TOPK cko mice (Fig. 5B). This evidence concerns the gene PBK and psoriasis.