ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; BL, baseline; BOLD, blood oxygenation-level dependent; CKD, chronic kidney disease; CV, cardiovascular; eGFR, estimated glomerular filtration rate; ESKD, end-stage kidney disease; GLP-1 RA, glucagon-like peptide-1 receptor agonist; LVEF, left ventricular ejection fraction; MI, myocardial infarction; MRI, magnetic resonance imaging; SGLT2i, sodium-glucose cotransporter-2 inhibitor; T2D, type 2 diabetes; UACR, urine albumin-to-creatine ratio. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.